The Cleveland Axis

The Cleveland Clinic Foundation

1.) Pregabalin (Lyrica): Pregabalin is FDA-approved for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and as an adjunct therapy for patients with partial-onset seizures. Although it is a structural analogue of gamma-aminobutyric acid (GABA), its exact mechanism is unknown. Common adverse effects associated with pregabalin use include ...

The aftermath of Cleveland.

The Cleveland Clinic Way

The global healthcare market continues to rapidly evolve, so it is important for all healthcare practitioners to be equally adept in their management of healthcare delivery as in their practice of medicine. A recent book by Toby Cosgrove MD, the CEO and president of the Cleveland Clinic, offers exquisite insight into transforming the institution’s healthcare delivery and outcomes to meet the 21...

NovoSeven: Cleveland Clinic Guidelines

In This Issue: • NovoSeven • Therapeutic Interchanges Introduction: Recombinant human activated Factor VII (rFVIIa), or NovoSeven, is a hemostatic agent which is structurally similar to human plasma-derived coagulation Factor VIIa. Recombinant FVIIa is currently licensed by the US Food and Drug Administration (FDA) in patients with hemophilia A or B with inhibitors to Factor VIII or Factor IX o...

The Cleveland Museum of Natural History

A small sample of hyracoid fossils from the late Miocene (,6.1 Ma) deposits at Lemudong’o, Narok, Kenya, belong to Dendrohyrax. This genus was unknown in the fossil record until recently, when almost simultaneously it was discovered at Lukeino (6 Ma) and Lemudong’o, both in Kenya. The fossils from Lemudong’o belong to a small species of the genus, not very different from Dendrohyrax validus. Th...